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KMID : 0381920070370010011
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Korean Journal of Microscopy
2007 Volume.37 No. 1 p.11 ~ p.21
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The Effects of Saengshik on the Hepatotoxicity of Mouse Induced by Carbon Tetrachloride
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Kim Dong-Hee
Deung Young-Kun
Lee Young-Mi
Yoon Yang-Suk
Lee Kyu-Jae
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Abstract
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Saengshik which is food not to apply heat is expected to have good effect on the body because metabolic enzymes are preserved in it. In fact, despite of enlargement of saengshik market, the researches on the effect of saengshik are insufficient. So, the aim of this study was to investigate the protective effect of saengshik against CCl4-inducing epatotoxicity in ICR mice. As the result of serum biochemical parameters, AST (SGOT) and ALT (SGPT) were significantly decreased at the experimental group treated with saengshik and CCl4 as compared with experimental group 1 treated with
CCl4 only (p?0.01). ALP was significantly higher at experimental group 2 compared with control and experimental group 1 (p?0.01). In histological study, experimental group 1 treated with CCl4 only showed severe necrosis all over the liver at the gross observation, and showed severe perivenular necrosis and individual hepatocytic degeneration. However xperimental group 2 was not nearly different from control group in appearance and showed mild perivenular necrosis and dominant sever neutrophil infiltration surrounding central veins.The result of this study showed the protective effect against CCl4-inducing hepatotoxicity and suggest the possibility of the functional health food. However, further studies about the effect of saengshik may be needed.
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KEYWORD
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Saengshik, Hepatotoxicity, CCl4, Liver
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